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Document Type |
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Article In Journal |
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Document Title |
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Association Between Interleukin-l Genotype and Periodontal disease within a well controlled diabetic population Association Between Interleukin-l Genotype and Periodontal disease within a well controlled diabetic population |
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Document Language |
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English |
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Abstract |
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Periodontal disease is a recognized complication of diabetes mellitus.
Recently, it has become evident that for many common chronic diseases,
modifying factors amplify disease mechanisms to make the clinical condition
more severe. Data suggest that factors, which amplify the inflammatory
process, such us diabetes and genetic influences, increase the relative risk for
severity of periodontitis.
Objectives: The aim of this report was to investigate the prevalence of
periodontal disease in a well-controlled diabetic population, and to establish
its association with IL-l genotypes.
Methods: One hundred diabetic patients were randomly screened at the
endocrinology clinic of Boston University Medical Center. Periodontal
probing measurements were made and type of diabetes, duration of diabetes,
level of control (glycosylated hemoglobin) and demographic data were
recorded. Periodontal disease was defined as two or more teeth with
periodontal pockets of 5 or more mm depth. Finger-stick blood samples were
collected and analyzed at the Department of Molecular Genetics and
Medicine at the University of Sheffield, United Kingdom, for genotyping of
IL-IA (+4845), IL-IB (+3954), IL-IB (-511), and IL-lra (+2018)
polymorphisms.
Results: The association between periodontal disease and genotype was
determined using Fisher's exact test. Among the diabetic patients in the study,
only IL-IB (-511) genotype (1.2 and 2.2 vs 1.1) was found to be associated
with periodontal disease in the African-American patients (p<0.05). The
frequency of allele 1 was 0.77 in periodontitis affected vs. 0.33 in healthy
diabetics. A borderline significant association between IL-IB (+3954) and
periodontal disease was also noted in Caribbean periodontal patients
(p=0.06); however, the allele 2 frequency in this population was only 10%.
Conclusions: These data confirm the high prevalence of periodontitis in the
diabetic population. Among diabetic patients, only IL-IB (-511) and IL-IB
(+3954) genotypes were found to have a tendency of association with
periodontal disease. |
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ISSN |
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0 |
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Journal Name |
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J Periodontol. |
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Volume |
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74 |
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Issue Number |
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8 |
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Publishing Year |
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2003 AH
2003 AD |
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Article Type |
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Article |
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Added Date |
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Tuesday, May 20, 2008 |
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Researchers
| ممدوح كريمه | Karima, Mamdouh | Researcher | Doctorate | mkarimah@kau.edu.sa |
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