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Document Type |
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Article In Journal |
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Document Title |
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Serum and salivary C3a concentration in human periodontitis . قياس تركيز الكمل الدموي الناعي الثالث في البلازما واللعاب في حالات التهاب اللثة والأنسجة الدعامية للاسنان |
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Document Language |
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English |
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Abstract |
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Periodontal disea"es comprise a group ef inflammatory conditions
affecting the supporting structures of the teeth. Periodontitis
may begin as gingivitis which spread to the underlying tissues.
Adult periodontitis' (A p) denote most forms of periodontitis in
adults, while the term juvenile periodontitis (JP) describes relatively
a rare forms of rapidly progressing periodontitis affecting ten
ages and young adults.
'l'he role of eomplernent system in the inflammatory response
of the periodontium has been reported by Mergenhagen et al. (1970)
The eomplement eomponents are inaetive precursors protein present
in serum and extracellular fluids. Complement activation leads to
generatioll of intJall1matory mediators which may cause host tissue
damage (Attsfroll1 et aI., H)75). Activation of complement can
occure by several pathways; the classical, One which is trigg6red by
immune complexes and involves S 1, C 2, the alternative pathway,
tr ggered by polysaeeharides, lipopolysaccharides component. The
alternative pathway begins by deavage of C 3 component into tow small frogments C 3a and C 3b ('l'sai et ad., 1977). C 3a fragment is
responsible for chemotaxis of FMNI J and phagocytic cells as well as
anaphylatoxine release which occures in early stages of periodontal
intiammation (Tollel'sen and Saltvedt, 1980).
Several investigators demonstrated the presence of different
complement fragments in gingival fluids as C 3a which result from
activation of C 3 by alternative pathway in response to dental plaque
and their products ( Ward 1967, Niekrashi et a!. , 1984) and
( Kristoffersen, 1985 ).
The purpose of the present investigation is to compare the level
of C 3a in serum with that in saliva in cases of chronic gingivitis,
marginal periodontitis and juvenile periodontitis. |
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ISSN |
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0 |
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Journal Name |
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EGYP'TAN DENTAL JOURNAll |
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Volume |
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35 |
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Issue Number |
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3 |
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Publishing Year |
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1989 AH
1989 AD |
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Article Type |
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Article |
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Added Date |
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Sunday, November 8, 2009 |
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Researchers
| زينب عبداللطيف | abdulatif, zenab | Researcher | Doctorate | |
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