Document Details

Document Type : Thesis 
Document Title :
Assessment of secretory immunoglobulins (s.IgA) and cariogenic bacteria in stimulated saliva of mothers and children with severe early.childhood caries (SECC)
Assessment of secretory immunoglobulins (s.IgA) and cariogenic bacteria in stimulated saliva of mothers and children with severe early.childhood caries (SECC)
 
Document Language : English 
Abstract : Early childhood caries (ECC) is recognized as an infectious disease. The first step in its development is primary infection by the bacterium S. mutans which has been identified as the primary etiologic factors in dental caries. Lactobacilli were also found to play a role in the progression of disease. However, the underlying mechanism of immune response to caries is unclear. The association between secretory IgA (s.IgA) and cariogenic microorganisms is still controversial. The purpose of this study was to assess the level of cariogenic bacteria and salivary IgA in caries free children, and children with SECC and their corresponding mothers. The study also aims at correlating the children's levels to their mothers'. Sixty children and their mothers attending the dental clinic in King Abdulaziz University participated in our study. Their age ranged from 3 - 5 years. The study groups consisted of thirty children with SECC and a control group consisting of thirty caries free children. Children together with their mothers were examined and their caries level was recorded. Stimulated saliva was collected from each participant for bacterial and immunological assessment. The secretory IgA (s. IgA) level was assessed by ELISA test and the S. mutans and Lactobacilli counts in each sample were determined, using the Dento cult methods Our study has shown that children with SECC and their mothers had shown higher levels of s. IgA than caries free children and mothers. A positive high correlation was found between secretory IgA of mothers and children in both groups. Children with SECC had higher levels of S. mutans and Lactobacilli than caries free children. The mothers of children with SECC had a statistically higher count of Lactobacilli than caries free children's mothers. However, the difference was not statistically significant with respect to their S. mutans counts. Meanwhile, a significant correlation exists between mothers and children with SECC with respects to S. mutans. 
Supervisor : Prof.NajlaaMohammedAIAmoudi 
Thesis Type : Master Thesis 
Publishing Year : 1426 AH
2005 AD 
Co-Supervisor : Prof.Azza Hanno 
Added Date : Sunday, February 14, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حنين الشكريAI Shukairy, Haneen ResearcherMaster 

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