Document Details Document Type : Article In Journal  Document Title : THE ANALGESIC EFFECTS OF MISWAK THE ANALGESIC EFFECTS OF MISWAK   Document Language : English  Abstract : Miswak (the root and branches of Salvadora persica) decoction was traditionally implicated as possessing analgesic activities against some form of denial pain. The purpose of this study was to determine whether miswak decoction has an analgesic effect and to describe the antinociceptive profile of miswak. Three analgesic tests (hot plate, writing reflex, and tail nick) were used. Miswak decoction was injected inrraperitoncally into MFI mice in dose volumes of 0.3 - 12.5 nil/kg 15 min. before the analgesic tests. Results showed that miswak decoction lowers mice's response to chemical and thermal stimuli in dose dependent manner. The effective dose 50 (ED50) were 3-5, 0.45, and 5-5 ml/kg for hot plate, tail flick, and writhing reflex tests, respectively. The analgesic effects of miswak decoction in the three (esis were antagonized by prior treatment by Naloxonc (0.4 mg/kg). It was concluded that miswak has an analgesic effect which is apparently mediated via interaction with central and/or peripheral opiated pathway.  ISSN : 0  Journal Name : the saudi dental journal  Volume : 8  Issue Number : 3  Publishing Year : 1996 AH 1996 AD  Article Type : Article  Added Date : Sunday, December 9, 2007  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email طارق الخطيب Al-Khateeb, Tarek Investigator Doctorate   Files File Name Type Description  THE ANALGESIC EFFECTS OF MISWAK.pdf pdf   Back To Researches Page