Document Details
|
Document Type |
: |
Article In Conference |
|
Document Title |
: |
Interlculdn -6 and Tumor Necrosis Factor-alpha in Gingival Crevicular Fluid of Smoking and Non-Smoking Chronic and AggressivePeriodontitis Patients. الأنترلوكين-6 وعامل النخر الورمي في السائل الحول اللثوي عند مرضى التهاب النسيج الجاعم حول السني المزمن والشرس في المجدنين وغير المدخنين |
|
Document Language |
: |
English |
|
Abstract |
: |
The local host response to periodontitis has been studied by biochemical analysis of gingival
crevicl!lar fluid (GCF). GCF cytokines, such as interleukin-6 (IL-6) and tumor necrosis
factor-alpha (TNF:.a.), have been shown to have a role in regulating the cellular inflammatory
response in the periodontium. Tobacco smoking is strongly associated with destructive
periodontal disease, although the mechanisms of its negative influence are not well
understood. The aim of this study was to determine the levels of IL-6 and TNF-a in the GCF
of chronic (CP) and aggressive (AP)periodontitis patients,and to investigate the relationship
between these cytokines and smoking. A total of 36 subjects participated into the study,
classified as 20 generalized CP patients, further subdivided into 10 smokers (S) and 10 nonsmokers
(NS); 16 generalized AP patients, further subclassified into 8 Sand 8 NS. The CP
patients had severe periodontitis to match the periodontal destruction seen in the AP group.
For standardization, smokers were chosen as being heavy smokers (at least 20 cigarettes/day).
Initial periodontal therapy was perfom1ed to all patients to match amooot of plaque, and 1
month post surgery was considered baseline. Clinical parameters including plaque index (PI),
retention index (RI), papillary bleeding index (pBI), probing depth (PD) and clinical
attachment level (CAL) were recorded at baseline and 3 months post treatment. Full mouth
periapical radiographs were taken at baseline and alveolar bone destruction was assessed by
the Schei method for diagnosis. GCF was collected by means of filter paper ftom four sites
per patient (with the most severe destruction) at same time intervals. The contents of IL- 6
and TNF-a were measured in using ELISA assays. At baseline, all clinical variables did not
show significant differences between Sand NS in CP patients, except for significant lower
PBI in S than NS. At 3 months, S CP patients revealed significantly higher PI and RI scores,
whereas NS showed significant reduction in CAL. AP patients demonstrated the same results,
but CAL scores did not improve significantly at 3 months in NS. S CP and AP patients
demonstrated a non-significant increase in GCF IL-6 and TNF-a concentrations, when
compared to NS. In both groups;- NS showed a significant decrease in GCF IL-6
concentrations at 3 months compared to baseline. S CP and AP patients showed a significant
increase in GCF TNF-a at baseline compared to NS, in addition to a significant decrease in
NS at 3 months compared to baseline. GCF IL-6 concentration showed significant negative
correlation with PD in NS CP patients, and significant positive correlation ,~tIt PBI in NS AP
patients; whereas GCF TNF-a revealed significant negative correlation with RI in S CP
patients. In conclusion, the enhanced production of inflammatory cytokines in the presence of
smoking may have clinical consequences, and may elucidate the mechanism of negative
influence of tobacco smoking on the periodontium. The reduced improvement following
periodontal therapy in S compared to NS may reflect the systemic effect of smoking on both
host response and healing process. |
|
Conference Name |
: |
المؤتمر الدولي الحادي عشر للجمعية المصرية لجراحي الاسنان |
|
Publishing Year |
: |
1423 AH
2003 AD |
|
Article Type |
: |
Article |
|
Added Date |
: |
Monday, October 18, 2010 |
|
Researchers
| غادة منصور | .Mansour, Ghada | Investigator | Doctorate | |
|
Back To Researches Page
|