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Faculty of Dentistry
Document Details
Document Type
:
Article In Journal
Document Title
:
Screeningfor humanpapillomavirus (HPV)in Egyptian womenbythe second-generation hybridcapture(HCII) test
Screeningfor humanpapillomavirus (HPV)in Egyptian womenbythe second-generation hybridcapture(HCII) test
Document Language
:
English
Abstract
:
HPV infection is the main cause of cervical cancer and cervical intraepithelial neoplasia worldwide. The second-generation HC II test is a liquid hybridization assay designed to detect 18 HPV types. The aim of the present stUdy was to detect the rate of HPV infection and its various genotypes among Egyptian women. We evaluated 166 Egyptian women. They were classified according to cytology inw those with normal cytology, chronic nonspecific cervicitis, and squamous intraepitheliallesions (SILs). The overall prevalence of HPV DNA in the studied groups was 15.06% (25/166). Among the 25 HPV-positive women, 16 (64%) were infected with high-risk HPV types. 4 (l(j%) with low risk HPV types, while 5 (20%) had both types. Twenty-one (84%) of the infected women harbored at least one high-risk HPV type. while 9 (36%) harbored at least one low-risk lIP\, lype. Values of HPV viral load for low-risk HPV infection showed no si~nificant difference in the normal and chronic nonspecific cervicitis groups. But when HPV viral load of high-risk HPV infection was compared in the normal, chronic nonspecific cervicitis, and SIL groups, a significant difference was found. The same was detected belween chronic nonspecific cervicitis and SIL and belween normal cytology and SIL, suggesting an association between viral load and risk of SIL and. accordingly, cancer. It may be concluded that HPV testing using the HC II assay is a useful tool when combined
ISSN
:
0
Journal Name
:
MedSciMani
Volume
:
12
Issue Number
:
7
Publishing Year
:
1426 AH
2006 AD
Article Type
:
Article
Added Date
:
Tuesday, February 7, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
دعاء الديروي
EI Derwi, Douaa
Researcher
Doctorate
Files
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Type
Description
32198.pdf
pdf
32199.pdf
pdf
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